… A treatment strategy that involves a ketone ester diet is novel and has promise as an
alternate therapy to the current clinical regimes for the management of AD. In the …

… -old 3xTgAD mice, led to an elevation in serum ketone body levels, … Effects of a dietary
ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids …

… The 3xTg AD mouse model expresses three mutations linked … phosphorylation or to make
ketone bodies that can serve as … Glycolysis anaerobically breaks down glucose molecules to …

… for ketone body generation from fatty acids and amino acids [… two AD mouse models, ie,
APP/PS1 and 3xTg-AD, EAAT2 … impaired glycolysis and TCA cycle, all of which adversely impact …

… approaches that produce ketone bodies for energy metabolism, … , 5xFAD mice fed a 4-month
KD had reduced hippocampal Aβ … 3xTg-AD mice fed an 8-month 43.5% carbohydrate diet …

… diseases such as Alzheimer’s disease. This decreased … a reduction of several glycolysis
intermediates in the … enhancing levels of circulating ketone bodies, KD usually lacks …

… ), APP/PS1 mice, 3xTg-AD (triple-transgenic mouse model … of ketone bodies and has a
lasting cognition-improving effect in … bypass of the glycolytic pathway [86, 173, 188]. In the brain, …

… , including amino acids, ketone bodies (KB), and fatty acids [30,… In 3xTgAD mice, KE had no
effect on ATP hydrolysis in the … shifting to mitochondrial respiration over glycolysis [121,122]. …

… KD increases ketone body (KBs) production and its concentration in … the glycolytic
pathway by directly entering the TCA cycle, … cycle intermediates, such as decreased C4-intermediate …

… The ketone ester diet in a model of AD (3xTgAD) had … OOA performed in mice showed
positive effects on glycolysis, … of mitochondrial biogenesis, hippocampal neurogenesis activity, …